Call for Research Proposals
Swine Health Information Center Call for Swine Disease Pathogen Detection Research Proposal
The Swine Health Information Center is asking for preliminary proposal(s), in a standardized form provided by the Center, from laboratories interested in performing Swine Disease Matrix antigen detection research. The Center is asking for laboratories to identify up to five of the pathogens on the Swine Disease Matrix for which the laboratory has the interest and capacity to conduct the research and then to submit a one-page SHIC preliminary proposal form for each of the pathogens of interest.
Also included in the preliminary proposal(s) for each pathogen should be a brief description of the laboratory’s plan for ensuring that the pathogen will not be introduced into the U.S. if it is not currently endemic. That description could include plans for international collaborations, biosecurity/biocontainment facilities or other methods. The important criteria for selection are the lab’s interest, capacity and biocontainment plan. There is no need to try to select “high priority” viruses for the project.
Swine Health Information Center Call for Seneca Valley Virus Research Proposals
There are reports of increased discovery of Seneca Valley Virus (SVV) in pigs in the United States and Brazil. The Swine Health Information Center is soliciting proposals to investigate SVV epidemiology and diagnostics capability.
Proposals must be submitted in the required format provided with the RFP in order to be considered. Interlaboratory collaboration that strengthens the proposal will be a factor in funding decisions. All funded projects are expected to be completed within 6 months of funding. Final funding decisions will be made by the Swine Health Information Center.
Proposals should be emailed to firstname.lastname@example.org and must be received by 5:00 PM CDT September 21, 2015.
Further enquiries regarding this solicitation can be directed to Dr. Paul Sundberg by email at email@example.com or by phone: 515-451-6652.
The pathogenicity of SVV in swine remains unclear. Its relevance lies mainly in its suspected link to idiopathic vesicular disease and resemblance to more clinically and economically disruptive vesicular FADs. Multiple cases of swine with vesicular lesions in the United States have been reported in which SVV was the only detected pathogen.
The Swine Health Information Center would like to investigate the pathogenicity of SVV in pigs through testing Koch’s Postulates using:
- a historic, endemic strain known to be present in the United States,
- a contemporary U.S. strain associated with a more severe clinical presentation than what would be historically expected, and
- an isolate associated with severe clinical presentation in Brazil.
The study design should consider pigs with normal immune status compared to pigs immunocompromised by a standardized immunocompromising protocol, standardized transport, and/or other stressors.
Characterization of the Virus
The Swine Health Information Center would like to characterize historical and contemporary U.S. SVV isolates and Brazilian SVV isolates in order to determine genetic differences among strains that could affect specificity of diagnostic tests and/or be associated with more severe clinical presentation.
The Swine Health Information Center would like to have developed new antibody detection assays that provide more rapid, cost-effective detection to assist diagnostic discovery in tissues or sera and to differentiate SVV from other disease agents of swine that cause vesicular lesions.
It is the policy of the Swine Health Information Center to not pay indirect or overhead charges for research conducted at public institutions and universities. If you have any questions, please contact SHIC at firstname.lastname@example.org.